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Uses of Titanium Nitride Ceramic Materials in Biomedicine

What does titanium nitride mean?

Titanium dioxide has a NaCl type structure. This is a cubic cubic lattice with constant lattice of a=0.4241nm in which titanium atoms reside at the corners. TiN can be altered within certain limits without altering the TiN composition. TiN powder can be found in yellow to brown colors, while the fine TiN powder can be black. TiN crystals have a golden color. TiN is very resistant to thermal shock, has a melting point of 2950oC, a density of 5.43-5.44g/cm3, Mohs toughness of 8-9 and a high temperature of 2950oC. TiN has a melting point that is greater than many transition metals nitrides. However, its density is much lower than the most transition metal nitrides. This makes it a highly heat-resistant and distinctive material. TiN has a crystal structure similar to TiC but the C atoms have been replaced by N atoms.

Biomedicine uses Titanium Nitride

In clinical medicine, the implant has been used extensively as an implant to provide interventional treatment for congenital heart disease. It is used to treat atrial septal defect, patent ductus arteriosus, and ventricular septal defect. The majority of concentric occluders made from nickel-titanium alloy materials contain at least 55% nickel. The long-term consequences of excessive nickel exposure can lead to allergies or poisoning in the human body. Surface purification membranes of the occluder nickel–titanium alloy can be damaged. Internal nickel ions released in complex environments of the body may increase nickel content. This will further deteriorate tissue compatibility.

According to relevant studies, titanium nitride is an alloy with excellent biocompatibility. It was previously used as a coronary stent material. The thrombus origin of this metal is therefore much lower that that of nickel-titanium. To address this medical issue, Cera ceramic membrane has been developed using high-energy Ion precipitation coating technology. It maintains the original interventricular and atrial septal obstructions, which are based on the original nickel/titanium alloy-based occluder. Patent ductus arteriosus and the design of this occluder use plasma technology to uniformly coat a titanium nitride TiN layer on the nickel-titanium alloy powder. The occluder’s corrosion resistance is dramatically improved by using ion tech. The Cera ceramic membrane is superior to ordinary nickel-titanium in terms of cell creeping performance, as evidenced by the animal experiment results. It reduces the risk for congenital heart defects, improves healing times and decreases the likelihood of thrombosis. Platelet adhesion rates and hemolysis are lower than with ordinary nickel-titanium. Cera has currently been approved by Russia, India, Brazil and Russia. The Cera occluder has been approved by the European Union, India, Brazil and Russia for use in congenital heart diseases.

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